1,3-DIPOLAR CYCLOADDITION AS THE KEY REACTION IN THE SYNTHESIS OF POTENT RENIN INHIBITORS

被引：13

作者：

BENZ, G ^{[1
]}

HENNING, R ^{[1
]}

STASCH, JP ^{[1
]}

机构：

[1] BAYER AG,PH FE,W-5600 WUPPERTAL 1,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 12期

关键词：

D O I：

10.1002/anie.199117021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Substituted allylamines like 1 react with nitrones 2 by 1,3-dipolar cycloaddition to form isoxazolidines 3, which are separable by chromatography. Hydrogenolytic opening of the isoxazolidines yields 1,3-amino alcohols, which when built into the angiotensinogen sequence, lead to renin inhibitors of type 4.

引用

页码：1702 / 1704

页数：3

共 20 条

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[2]

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[3]

FEHRENTZ JA, 1983, SYNTHESIS-STUTTGART, P676

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