TREATMENT WITH IL2/VACCINIA RECOMBINANT VIRUS LEADS TO SEROLOGIC, HISTOLOGIC AND PHENOTYPIC NORMALIZATION OF AUTOIMMUNE MRL/LPR-LPR MICE

被引：15

作者：

GUTIERREZRAMOS, JC

ANDREU, JL

MARCOS, MAR

VEGAZO, IR

MARTINEZ, C

机构：

[1] Centro de Biologia Molecular (CSIC-UAM), Universidad Autonoma de Madrid, Madrid, Campus de Cantoblanco

[2] Institute Pasteur, Paris, Cedex

[3] Clinica Puerta de Hierro, 28035, Madrid

[4] Basel Institute for Immunology, Basel

来源：

AUTOIMMUNITY | 1991年 / 10卷 / 01期

关键词：

LYMPHOKINES; VIRUS VECTOR DELIVERY SYSTEM; T-CELLS; AUTOIMMUNE DISEASE;

D O I：

10.3109/08916939108997143

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have analyzed the effect of IL2 administered in vivo on both the lymphoproliferation and autoimmune disease progression of MRL/lpr mice. Human IL2 was delivered by infecting MRL/lpr mice with vaccinia virus recombinants at different stages of lpr disease. The results reported here showed that treatment of lpr mice with IL2 mediated: (I) restored normal thymic differentiation illustrated by an expansion of the double positive population accompanied by increased numbers of mature thymocytes; (2) depletion of the peripheral CD3+CD4+CD8-(DN) T-cell population, which is abnormally expanded in lpr mice, and a consequent restoration of the normal mature T cell population; (3) normalization in the pattern of TcRVβ gene expression displayed by mature T cells; (4) decreased urine-protein levels and immune complex deposition in the kidney, with a resultant absence of glomerulonephritis; and (5) an increased longevity (from 195 to more than 400 days). We speculate that the dramatic reduction in the abnormally expanded CD3+DN T-cell population following IL2 therapy might be directly related to the amelioration and/or prevention of autoimmune disease in these mice. Collectively, these results suggest that diseases showing a selective expansion of DN cells should be envisaged as possible targets for the treatment described here. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：15 / 25

页数：11

共 46 条

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