PHARMACOKINETIC AND METABOLIC ASPECTS OF THE MOCLOBEMIDE-FOOD INTERACTION

被引：4

作者：

COLE, AFD

BAXTER, JG

JACKSON, BJ

HEWWING, P

GUNTERT, TW

LALKA, D

机构：

[1] W VIRGINIA UNIV, SCH PHARM, DEPT BASIC PHARMACEUT SCI, MORGANTOWN, WV 26506 USA

[2] MT SINAI HOSP, DEPT ANAESTHESIA, TORONTO M5G 1X5, ONTARIO, CANADA

[3] SUNY BUFFALO, SCH PHARM, DEPT PHARMACEUT, BUFFALO, NY 14260 USA

[4] F HOFFMANN LA ROCHE & CO LTD, DEPT CLIN PHARMACOL, CH-4002 BASEL, SWITZERLAND

来源：

PSYCHOPHARMACOLOGY | 1992年 / 106卷

关键词：

MOCLOBEMIDE; PHARMACOKINETICS; INTERACTION; FOOD EFFECT;

D O I：

10.1007/BF02246232

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC-up) and on systemic clearance (AUC-down) balance each other out.

引用

页码：S37 / S39

页数：3