NEW INTRACELLULAR TARGETS FOR THERAPEUTIC DRUG DESIGN

被引：101

作者：

BRUGGE, JS

机构：

[1] ARIAD Pharmaceuticals, Inc., Cambridge, MA 02139-4234

来源：

SCIENCE | 1993年 / 260卷 / 5110期

关键词：

D O I：

10.1126/science.8388123

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：918 / 919

页数：2

共 12 条

[1] STRUCTURE OF AN SH2 DOMAIN OF THE P85-ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE [J].

BOOKER, GW ;

BREEZE, AL ;

DOWNING, AK ;

PANAYOTOU, G ;

GOUT, I ;

WATERFIELD, MD ;

CAMPBELL, ID .

NATURE, 1992, 358 (6388) :684-687

[2] ONCOGENES AND SIGNAL TRANSDUCTION [J].

CANTLEY, LC ;

AUGER, KR ;

CARPENTER, C ;

DUCKWORTH, B ;

GRAZIANI, A ;

KAPELLER, R ;

SOLTOFF, S .

CELL, 1991, 64 (02) :281-302

[3] DISTINCT PHOSPHOTYROSINES ON A GROWTH-FACTOR RECEPTOR BIND TO SPECIFIC MOLECULES THAT MEDIATE DIFFERENT SIGNALING PATHWAYS [J].

FANTL, WJ ;

ESCOBEDO, JA ;

MARTIN, GA ;

TURCK, CW ;

DELROSARIO, M ;

MCCORMICK, F ;

WILLIAMS, LT .

CELL, 1992, 69 (03) :413-423

[4] SH2 DOMAINS EXHIBIT HIGH-AFFINITY BINDING TO TYROSINE-PHOSPHORYLATED PEPTIDES YET ALSO EXHIBIT RAPID DISSOCIATION AND EXCHANGE [J].

FELDER, S ;

ZHOU, M ;

HU, P ;

URENA, J ;

ULLRICH, A ;

CHAUDHURI, M ;

WHITE, M ;

SHOELSON, SE ;

SCHLESSINGER, J .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1449-1455

[5]

JACOBS G, 1990, New Biologist, V2, P583

[6] SH2 AND SH3 DOMAINS - ELEMENTS THAT CONTROL INTERACTIONS OF CYTOPLASMIC SIGNALING PROTEINS [J].

KOCH, CA ;

ANDERSON, D ;

MORAN, MF ;

ELLIS, C ;

PAWSON, T .

SCIENCE, 1991, 252 (5006) :668-674

[7] THE LEUCINE ZIPPER - A HYPOTHETICAL STRUCTURE COMMON TO A NEW CLASS OF DNA-BINDING PROTEINS [J].

LANDSCHULZ, WH ;

JOHNSON, PF ;

MCKNIGHT, SL .

SCIENCE, 1988, 240 (4860) :1759-1764

[8] SH2 AND SH3 DOMAINS - FROM STRUCTURE TO FUNCTION [J].

PAWSON, T ;

GISH, GD .

CELL, 1992, 71 (03) :359-362

[9] TRIGGERING SIGNALING CASCADES BY RECEPTOR TYROSINE KINASES [J].

PAZIN, MJ ;

WILLIAMS, LT .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (10) :374-378

[10]

SAMELSON LE, 1992, J BIOL CHEM, V267, P24913

← 1 2 →