ANTIINFLAMMATORY ACTIVITY OF AMINE-CARBOXYBORANES IN RODENTS

被引：21

作者：

HALL, IH ^{[1
]}

RAJENDRAN, KG ^{[1
]}

CHEN, SY ^{[1
]}

WONG, OT ^{[1
]}

SOOD, A ^{[1
]}

SPIELVOGEL, BF ^{[1
]}

机构：

[1] BORON BIOL INC,RALEIGH,NC 27636

来源：

ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 01期

关键词：

D O I：

10.1002/ardp.19953280108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Amine-carboxyboranes are potent anti-inflammatory agents reducing induced edema and pleural effusion at 8 mg/Kg, i.p. They protect against LPS (Salmonella) induced septic shock from 2-8 mg/Kg/day and are effective in blocking pain mediated both locally and centrally. The mode of action of these agents is by blocking release of cytokines from macrophages, thus reducing lysosomal hydrolytic and proteolytic enzyme activities of affected cells. The agents also reduce prostaglandin and leukotriene synthesis by blocking the activities of regulatory enzymes of the respective pathways.

引用

页码：39 / 44

页数：6

共 34 条

[1] TOXIC EFFECTS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN A HUMAN INTESTINAL EPITHELIAL-CELL LINE (HCT-8), AS ASSESSED BY THE MTT AND NEUTRAL RED ASSAYS [J].