THE RELATIVE DEPENDENCE OF CALCIUM-ANTAGONISTS AND NEUROLEPTICS BINDING TO BRAIN AND HEART RECEPTORS ON DRUG LIPOPHILICITY

被引：5

作者：

ROJRATANAKIAT, W ^{[1
]}

HANSCH, C ^{[1
]}

机构：

[1] POMONA COLL, DEPT CHEM, CLAREMONT, CA 91711 USA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 08期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb07071.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— QSAR analysis of the binding of calcium antagonists to brain and heart tissue shows that relative binding to brain tissue increases with increasing octanol/water partition coefficients. A number of antischizophrenic drugs follow the same pattern. 1990 Royal Pharmaceutical Society of Great Britain

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页码：599 / 600

页数：2

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