CELLULAR B-2 MICROGLOBULIN EXPRESSION AS A PROGNOSTIC INDICATOR IN RENAL-CELL CARCINOMA

被引：11

作者：

LEVIN, I

KUPERMAN, O

GOLDSTEIN, J

NEUMANN, L

SEGAL, S

KANETI, J

LISMER, L

MACHPUD, A

KLEIN, B

机构：

[1] SOROKA MED CTR,INST PATHOL,IL-84101 BEER SHEVA,ISRAEL

[2] SOROKA MED CTR,EPIDEMIOL UNIT,IL-84101 BEER SHEVA,ISRAEL

[3] SOROKA MED CTR,IMMUNOL & MICROBIOL UNIT,IL-84101 BEER SHEVA,ISRAEL

[4] BEN GURION UNIV NEGEV,FAC HLTH SCI,IL-84105 BEER SHEVA,ISRAEL

[5] BEILINSON MED CTR,DEPT ONCOL,IL-49100 PETAH TIQWA,ISRAEL

[6] TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL

来源：

ACTA ONCOLOGICA | 1991年 / 30卷 / 08期

关键词：

RENAL CELL CARCINOMA; B-2; MICROGLOBULIN; SURVIVAL;

D O I：

10.3109/02841869109088247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of B-2 microglobulin (B-2M) on tumor cells and their normal cell counterparts in 39 patients with renal cell carcinoma was studied and correlated to tumor stage and survival. The median survival time of patients with localized disease (stage 1) whose tumors expressed B-2M was 10.2 years while the median survival time for patients whose tumors did not express B-2M was only 3.6 years (p < 0.001). For patients with more advanced disease (stages II, III, IV) whose tumors expressed B-2M, median survival time was 3.6 years compared to 2.0 years in patients whose tumors did not express B-2M, a non-significant difference. It is suggested that the tumor cell membrane expression of B-2M may serve as an indicator of good prognosis in early renal cell carcinoma.

引用

页码：941 / 945

页数：5

共 29 条

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