DNA IMMUNIZATION CONFERS PROTECTION AGAINST LETHAL LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION

被引：172

作者：

YOKOYAMA, M ^{[1
]}

ZHANG, J ^{[1
]}

WHITTON, JL ^{[1
]}

机构：

[1] SCRIPPS CLIN & RES FDN,DEPT NEUROPHARMACOL,LA JOLLA,CA 92037

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 04期

关键词：

D O I：

10.1128/JVI.69.4.2684-2688.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA vaccination has been evaluated with the lymphocytic choriomeningitis virus (LCMV) model system. Plasmid DNA encoding the LCMV nucleoprotein, when injected intramuscularly, induces both antiviral antibodies and cytotoxic T lymphocytes. Injection of DNA encoding the nucleoprotein or the viral glycoprotein confers protection against normally lethal LCMV challenge in a major histocompatibility complex dependent manner. The protection conferred is incomplete, but it is most probably mediated by the induced cytotoxic T lymphocytes.

引用

页码：2684 / 2688

页数：5