LINKAGE ANALYSIS IN A LARGE PEDIGREE ASCERTAINED DUE TO ESSENTIAL FAMILIAL HYPERCHOLESTEROLEMIA

被引：19

作者：

BAILEYWILSON, JE

WILSON, AF

BAMBA, V

机构：

[1] Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans, Louisiana

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 06期

关键词：

CHOLESTEROL; TRIGLYCERIDE; HEIGHT; WEIGHT; SIB-PAIR LINKAGE; BLOOD PRESSURE;

D O I：

10.1002/gepi.1370100656

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sib-pair linkage analysis was used to screen a large pedigree, ascertained through four members with hypercholesterolemia, for evidence of linkage between 12 quantitative traits and 15 genetic marker loci. Traits were analyzed on the untransformed, natural log and square root-transformed scales. After adjusting for multiple tests, there is a suggestion of linkage between height and the Kidd blood group on chromosome 18 and between VLDL cholesterol, and possibly triglyceride, and KM on chromosome 2. (C) 1993 Wiley-Liss, Inc.

引用

页码：665 / 669

页数：5

共 9 条

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