THE TREFOIL PEPTIDES SPASMOLYTIC POLYPEPTIDE AND INTESTINAL TREFOIL FACTOR ARE MAJOR SECRETORY PRODUCTS OF THE RAT GUT

被引：40

作者：

TAUPIN, DR ^{[1
]}

PANG, KC ^{[1
]}

GREEN, SP ^{[1
]}

GIRAUD, AS ^{[1
]}

机构：

[1] UNIV MELBOURNE,WESTERN HOSP,DEPT MED,MELBOURNE,VIC,AUSTRALIA

来源：

PEPTIDES | 1995年 / 16卷 / 06期

基金：

英国医学研究理事会;

关键词：

SPASMOLYTIC POLYPEPTIDE; INTESTINAL TREFOIL FACTOR; TREFOIL PEPTIDE; GUT; MUCUS CELL;

D O I：

10.1016/0196-9781(95)00070-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spasmolytic polypeptide (SP) and intestinal trefoil factor (ITF) are trefoil peptides expressed by gut mucus cells. Using specific antisera we have quantified and characterized the molecular forms and distribution of these peptides in the rat gut. SP predominates in the gastric antrum as a 12 kDa form. ITF (7 kDa) is highly expressed throughout the small intestine. Both peptides are distributed in the apical secretory compartment of antral mucus cells (SP) and goblet cells (ITF), and on the lumenal surface. This study quantifies SP and ITF for the first time, and confirms them as major secretory products of the rat gut.

引用

页码：1001 / 1005

页数：5

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