INFLAMMATION-INDUCED CHANGES IN EXPRESSION AND GLYCOSYLATION OF GENETIC-VARIANTS OF ALPHA-1-ACID GLYCOPROTEIN - STUDIES WITH HUMAN SERA, PRIMARY CULTURES OF HUMAN HEPATOCYTES AND TRANSGENIC MICE

被引：50

作者：

VANDIJK, W

POS, O

VANDERSTELT, ME

MOSHAGE, HJ

YAP, SH

DENTE, L

BAUMANN, P

EAP, CB

机构：

[1] UNIV HOSP GASTHUISBERG,DIV LIVER & PANCREAT DIS,B-3000 LOUVAIN,BELGIUM

[2] NAPLES UNIV,FAC MED & CHIRURG 2,DIPARTIMENTO BIOCHIM & BIOTECNOL MED,I-80131 NAPLES,ITALY

[3] UNIV PRILLY LAUSANNE,HOP CERY,DEPT PSYCH ADULTE,UNITE BIOCHIM,CH-1008 PRILLY,SWITZERLAND

来源：

BIOCHEMICAL JOURNAL | 1991年 / 276卷

关键词：

D O I：

10.1042/bj2760343

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relative occurrence of genetic variants of human alpha-1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.

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页码：343 / 347

页数：5

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