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THE NEUROPROTECTIVE PROPERTIES OF IFENPRODIL, A NOVEL NMDA RECEPTOR ANTAGONIST, IN NEURONAL CELL-CULTURE TOXICITY STUDIES

被引：28
作者：
GRAHAM, D
DARLES, G
LANGER, SZ
机构：
[1] Department of Biology, Synthélabo Recherche (L.E.R.S.)
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 226卷 / 04期
关键词：
IFENPRODIL; NEUROTOXICITY; CELL CULTURE; NMDA RECEPTORS;
D O I：
10.1016/0922-4106(92)90056-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effect of ifenprodil on excitotoxic cell death induced by acute exposure to glutamate receptor agonists in primary cultures of foetal mouse cerebral cortex. L-Glutamate and N-methyl-D-aspartate (NMDA) but not kainate and quisqualate-induced toxicity was attenuated in the presence of ifenprodil. In addition, ifenprodil and MK-801 blocked NaCN-induced toxicity. It is concluded that the cerebro-protective properties of ifenprodil in these models are mediated by NMDA receptor antagonism.
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页码：373 / 376
页数：4
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