PHOSPHOINOSITIDE HYDROLYSIS LINKED 5-HT2 RECEPTORS IN FIBROBLASTS FROM CHOROID-PLEXUS

被引：14

作者：

BARKER, EL ^{[1
]}

BURRIS, KD ^{[1
]}

SANDERSBUSH, E ^{[1
]}

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT PHARMACOL,MED RES BLDG,NASHVILLE,TN 37232

来源：

BRAIN RESEARCH | 1991年 / 552卷 / 02期

关键词：

SEROTONIN RECEPTORS; CHOROID PLEXUS; HALLUCINOGENS;

D O I：

10.1016/0006-8993(91)90099-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A serotonin (5-HT)-mediated phosphoinositide hydrolysis response was characterized in fibroblasts cultured from rabbit choroid plexus. 5-HT elicited a maximum 8-fold increase in [H-3]inositol-phosphate ([H-3]IP) formation, while the partial agonists, (+)-lysergic acid diethylamide and (-)-1-(4-bromo-2,5-dimethyoxyphenyl)-2-aminopropane caused 2- and 5-fold increases, respectively. Mianserin, ketanserin, and spiperone were equipotent at blocking the 5-HT-mediated response. Thus, agonist and antagonist profiles indicate interactions with 5-HT2 receptors.

引用

页码：330 / 332

页数：3

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