1-OLEOYL-2-DOCOSAHEXAENOYL PHOSPHATIDYLCHOLINE INCREASED PARADOXICAL SLEEP IN F344 RATS

被引：4

作者：

HASHIMOTO, M ^{[1
]}

GONG, XW ^{[1
]}

IZAKI, Y ^{[1
]}

IRIKI, M ^{[1
]}

HIBINO, H ^{[1
]}

机构：

[1] NOF CORP,TSUKUBA RES LAB,IBARAKI,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 158卷 / 01期

关键词：

LECITHIN; 1-OLEOYL-2-DOCOSAHEXAENOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE; GLYCEROPHOSPHORYL-CHOLINE; ACETYLCHOLINE; FATTY ACID; PARADOXICAL SLEEP;

D O I：

10.1016/0304-3940(93)90604-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (O-DH-PC), a kind of lecithin, and of glycerophosphorylcholine (GPC) on sleep were investigated in male F344 rats. Intracerebroventricular administration of O-DH-PC at a dose of 10 mug/rat induced significant increase in paradoxical sleep time and total sleep time in the following 24 h, while administration of GPC did not. Results suggest that O-DH-PC affects on neuronal mechanism relating to paradoxical sleep, and that the effect of O-DH-PC might be caused by fatty acid residues, rather than choline residue.

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页码：29 / 32

页数：4

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