TUMOR-PROMOTING ABILITY OF MANCOZEB, A CARBAMATE FUNGICIDE, ON MOUSE SKIN

被引：15

作者：

SHUKLA, Y ^{[1
]}

ANTONY, M ^{[1
]}

KUMAR, S ^{[1
]}

MEHROTRA, NK ^{[1
]}

机构：

[1] IND TOXICOL RES CTR, ENVIRONM CARCINOGENESIS LAB, POB 80, LUCKNOW 226001, UTTAR PRADESH, INDIA

来源：

CARCINOGENESIS | 1988年 / 9卷 / 08期

关键词：

D O I：

10.1093/carcin/9.8.1511

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study the tumor-promoting activity of a carbamate fungicide, mancozeb, has been observed following topical application on mouse skin in a two-stage initiation.sbd.promotion protocol for carcinogenesis. Female Swiss albino mice were initiated with a single subcarcinogenic dose (52 .mu.g) of 7,12-dimethylbenz[a]anthracene painted on the interscapular region. Seven days after initiation the mice underwent topical application of mancozeb (100 mg/kg body wt) three times per week as promoter. Development of tumors was observed after 12 weeks of mancozeb application in 1/14 animals and 100% tumorigenesis was recorded after 17 weeks of mancozeb application. On histological examination, these tumors were found mostly to be benign in nature, e.g. squamous cell papillomas and keratocanthomas.

引用

页码：1511 / 1512

页数：2