DRUG TARGETING USING NONMAGNETIC AND MAGNETIC ALBUMIN-GLOBULIN MIX MICROSPHERES OF MEFENAMIC-ACID

被引：11

作者：

LALLA, JK

AHUJA, PL

机构：

[1] Department of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Worli Bombay

来源：

JOURNAL OF MICROENCAPSULATION | 1991年 / 8卷 / 01期

关键词：

D O I：

10.3109/02652049109021856

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemical parameters of the microspheres such as density, particle size distribution, surface topography and wall thickness, as well as the magnetite contained within the magnetic microspheres, have been determined. The infrared spectroscopic analysis confirmed the encapsulation of the drug and absence of free drug on the surface of the microspheres. The X-ray diffraction analysis confirmed that the crystallinity of the drug remained unchanged indicating thereby that no complex formation had taken place between core and coat materials. The in vitro release profiles of the microspheres have been studied. An attempt has also been made to check the in vivo efficacy in rats.

引用

页码：37 / 52

页数：16

共 20 条

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