RAT MODEL FOR A VASCULARIZED LARYNGEAL ALLOGRAFT

被引：36

作者：

STROME, S

SLOMANMOLL, E

WU, J

SAMONTE, BR

STROME, M

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,JOINT CTR OTOLARYNGOL,BOSTON,MA 02115

[2] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,SURG RES LABS,BOSTON,MA 02215

来源：

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | 1992年 / 101卷 / 11期

关键词：

ALLOGRAFT; NEW MODEL; TRANSPLANTATION;

D O I：

10.1177/000348949210101112

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

A new rat model was developed to reexamine the potential for laryngea transplantation. The final anatomic derivation evolved from two earlier developmental phases. The first model had only a single arterial anastomosis; the second had an end-to-end arterial anastomosis with an end-to-end arteriovenous shunt. The final product employed an end-to-side arterial shunt and an end-to-side arteriovenous shunt for revascularization. The allografts were sited in tandem with the intact recipient larynges and were not innervated. A total of 16 animals were studied in phase 3; 2 died and the remaining 14 had a 64% arterial patency at intervals of 1 to 14 days. Our purpose is to detail the relevant technical considerations of this new model and compare it with historical controls.

引用

页码：950 / 953

页数：4