PHENYLPHOSPHONATE MONOESTER ANALOGS OF COCAINE - POTENTIAL HAPTENS FOR THE GENERATION OF CATALYTIC ANTIBODIES

被引：14

作者：

CHANDRAKUMAR, NS

CARRON, CP

MEYER, DM

BEARDSLEY, PM

NASH, SA

TAM, LL

RAFFERTY, M

机构：

[1] SEARLE RES & DEV,CNS BIOL,SKOKIE,IL 60077

[2] MONSANTO CO,MONSANTO CORP RES,ST LOUIS,MO 63198

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80899-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple method for the stero-controlled preparation of phenylphosphonate monoesters which are transition state mimics for the hydrolysis of the benzoic acid ester moiety of cocaine is described. Some preliminary results on the use of these mimics for the development of antibodies are also presented.

引用

页码：309 / 312

页数：4

共 10 条

[1]

Adams E H, 1984, NIDA Res Monogr, V50, P9

[2] A POTENTIAL VACCINE FOR COCAINE ABUSE PROPHYLAXIS [J].