GROUP-A STREPTOCOCCAL-M PROTEINS - VIRULENCE FACTORS AND PROTECTIVE ANTIGENS

被引：89

作者：

ROBINSON, JH ^{[1
]}

KEHOE, MA ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE, SCH MED, DEPT MICROBIOL, NEWCASTLE UPON TYNE NE2 4HH, ENGLAND

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0167-5699(92)90173-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rebecca Lancefield described group A streptococcal M proteins over 50 years ago, and they have remained at the forefront of investigations into streptococcal pathogenicity to the present day. As described in this review, they form cell surface fibrils with several functions, ranging from resisting phagocytosis and inducing host-crossreactive antibodies, to presenting the host immune system with an accessible protective antigen.

引用

页码：362 / 366

页数：5

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