METABOLIC RESPONSE TO EXPERIMENTAL OVERFEEDING IN LEAN AND OVERWEIGHT HEALTHY-VOLUNTEERS

被引:149
作者
DIAZ, EO
PRENTICE, AM
GOLDBERG, GR
MURGATROYD, PR
COWARD, WA
机构
[1] Dunn Clinical Nutrition Centre, Cambridge CB2 1Q1
关键词
ADAPTIVE THERMOGENESIS; OVERFEEDING; BODY WEIGHT; OBESITY; ENERGY EXPENDITURE; WHOLE-BODY CALORIMETRY; DOUBLY LABELED WATER; SET-POINT REGULATION;
D O I
10.1093/ajcn/56.4.641
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Possible adaptive mechanisms that may defend against weight gain during periods of excessive energy intake were investigated by overfeeding six lean and three overweight young men by 50% above baseline requirements with a mixed diet for 42 d [6.2 +/- 1.9 MJ/d (xBAR +/- SD), or a total of 265 +/- 45 MJ]. Mean weight gain was 7.6 +/- 1.6 kg (58 +/- 18% fat). The energy cost of tissue deposition (28.7 +/- 4.4 MJ/kg) matched the theoretical cost (26.0 MJ/kg). Basal metabolic rate (BMR) increased by 0.9 +/- 0.4 MJ/d and daily energy expenditure assessed by whole-body calorimetry (CAL EE) increased by 1.8 +/- 0.5 MJ/d. Total free-living energy expenditure (TEE) measured by doubly labeled water increased by 1.4 +/- 2.0 MJ/d. Activity and thermogenesis (computed as CAL EE - BMR and TEE - BMR) increased by only 0.9 +/- 0.4 and 0.9 +/- 2.1 MJ/d, respectively. All outcomes were consistent with theoretical changes due to the increased fat-free mass, body weight, and energy intake. There was no evidence of any active energy-dissipating mechanisms.
引用
收藏
页码:641 / 655
页数:15
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