THE BEHAVIORAL-EFFECTS OF NEUROPEPTIDE-Y (NPY) INJECTION INTO THE RAT-BRAIN FRONTAL-CORTEX

被引：13

作者：

SMIALOWSKI, A ^{[1
]}

LEWINSKAGASTOL, L ^{[1
]}

SMIALOWSKA, M ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST PHARMACOL,NEUROBIOL LAB,SMETNA STR 12,PL-31120 KRAKOW,POLAND

来源：

NEUROPEPTIDES | 1992年 / 21卷 / 03期

关键词：

D O I：

10.1016/0143-4179(92)90038-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to investigate the influence of intracortical administration of neuropeptide-Y on the behaviour of rats. One week before the behavioural test the frontal cortex of rats was chronically implanted with intracerebral cannulae. Neuropeptide-Y (or saline in the control group) was injected in a volume of 1-mu-l. After treatment the behaviour of the rats was tested in an open field apparatus and a light-beam actometer. The number of line crossings, episodes of rearing, sniffing, washing and head poking were counted. The results indicate that administration of neuropeptide-Y to the frontal cortex of rats slightly increased exploratory and locomotor activity.

引用

页码：153 / 156

页数：4

共 28 条

[1] NEUROPEPTIDE-Y - ROLE IN LIGHT DARK CYCLE ENTRAINMENT OF HAMSTER CIRCADIAN-RHYTHMS [J].

ALBERS, HE ;

FERRIS, CF .

NEUROSCIENCE LETTERS, 1984, 50 (1-3) :163-168

[2] NEUROPEPTIDE-Y DISTRIBUTION IN THE RAT-BRAIN [J].

ALLEN, YS ;

ADRIAN, TE ;

ALLEN, JM ;

TATEMOTO, K ;

CROW, TJ ;

BLOOM, SR ;

POLAK, JM .

SCIENCE, 1983, 221 (4613) :877-879

[3]

AOKI C, 1989, J NEUROSCI, V9, P4333

[4] TESTS FOR EMOTIONALITY IN RATS AND MICE - REVIEW [J].

ARCHER, J .

ANIMAL BEHAVIOUR, 1973, 21 (MAY) :205-235

[5] THE ANATOMY OF NEUROPEPTIDE-Y-CONTAINING NEURONS IN RAT-BRAIN [J].

CHRONWALL, BM ;

DIMAGGIO, DA ;

MASSARI, VJ ;

PICKEL, VM ;

RUGGIERO, DA ;

ODONOHUE, TL .

NEUROSCIENCE, 1985, 15 (04) :1159-1181

[6] NEUROPEPTIDE-Y - LOCALIZATION IN THE CENTRAL-NERVOUS-SYSTEM AND NEUROENDOCRINE FUNCTIONS [J].

DANGER, JM ;

TONON, MC ;

JENKS, BG ;

SAINTPIERRE, S ;

MARTEL, JC ;

FASOLO, A ;

BRETON, B ;

QUIRION, R ;

PELLETIER, G ;

VAUDRY, H .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1990, 4 (03) :307-340

[7]

FINK JS, 1980, BRAIN RES, V199, P359

[8]

FUXE K, 1983, ACTA PHYSL SCAND, V118, P183

[9] NEUROPEPTIDE-Y - ANATOMICAL DISTRIBUTION AND POSSIBLE FUNCTION IN MAMMALIAN NERVOUS-SYSTEM [J].

GRAY, TS ;

MORLEY, JE .

LIFE SCIENCES, 1986, 38 (05) :389-401

[10] NEUROPEPTIDE-Y (NPY)-INDUCED SUPPRESSION OF ACTIVITY IN THE RAT - EVIDENCE FOR NPY RECEPTOR HETEROGENEITY AND FOR INTERACTION WITH ALPHA-ADRENOCEPTORS [J].

HEILIG, M ;

WAHLESTEDT, C ;

WIDERLOV, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 157 (2-3) :205-213

← 1 2 3 →