MILD ALCOHOL METHYLATION PROCEDURES FOR THE SYNTHESIS OF POLYOXYGENATED NATURAL-PRODUCTS - APPLICATIONS TO THE SYNTHESIS OF LONOMYCIN-A

被引：64

作者：

EVANS, DA

RATZ, AM

HUFF, BE

SHEPPARD, GS

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 39期

关键词：

D O I：

10.1016/0040-4039(94)85352-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Studies directed toward the formation of methyl ethers in key intermediates for the synthesis of lono-mycin A are described. Several highly functionalized secondary alcohols have been methylated in excellent yields using the powerful methylating reagents methyl triflate (MeOTf) and trimethyloxonium fluoroborate (Me(3)OBF(4)).

引用

页码：7171 / 7172

页数：2

共 8 条

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