6-DIMETHYLAMINO-9-(BETA-D-ARABINOFURANOSYL)-9H-PURINE - PHARMACOKINETICS AND ANTIVIRAL ACTIVITY IN SIMIAN VARICELLA VIRUS-INFECTED MONKEYS

被引：3

作者：

SOIKE, KF ^{[1
]}

HUANG, JL ^{[1
]}

LAMBE, CU ^{[1
]}

NELSON, DJ ^{[1
]}

ELLIS, MN ^{[1
]}

KRENITSKY, TA ^{[1
]}

KOSZALKA, GW ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,RES TRIANGLE PK,NC 27709

来源：

ANTIVIRAL RESEARCH | 1993年 / 20卷 / 01期

关键词：

PHARMACOKINETICS; NUCLEOSIDE; SIMIAN VARICELLA VIRUS; ANTIVIRAL;

D O I：

10.1016/0166-3542(93)90055-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

6-Dimethylamino-9-(beta-D-arabinofuranosyl)-9H-purine (ara-DMAP) effectively prevented the development of rash and appreciably reduced viremia in simian varicella virus-infected monkeys. Doses of 100 and 50 mg/kg/day, administered orally, were highly effective. The lowest dose of 20 mg/kg/day was much less effective in preventing moderate viremia. However, the 20 mg/kg/day did prevent the development of rash in two of three monkeys. All three doses of ara-DMAP reduced liver infection as reflected by lower aspartate amino-transferase values in the sera of the African green monkeys. Orally administered ara-DMAP was rapidly absorbed. However, significant variation among individual monkeys in the AUC values, peak plasma levels, and plasma half-lives were observed.

引用

页码：13 / 20

页数：8

共 6 条

[1]

Goodman L.S., 1985, PHARM BASIS THERAPEU

[2] 6-N-SUBSTITUTED DERIVATIVES OF ADENINE-ARABINOSIDE AS SELECTIVE INHIBITORS OF VARICELLA-ZOSTER VIRUS [J].