NERVE GROWTH-FACTOR INCREASES CORTICAL CHOLINE ACETYLTRANSFERASE-POSITIVE FIBER STAINING WITHOUT AFFECTING CORTICAL CHOLINERGIC NEURONS

被引：4

作者：

DEKKER, AJ

THAL, LJ

机构：

[1] VET ADM MED CTR,NEUROL SERV V127,3350 LA JOLLA VILLAGE DR,SAN DIEGO,CA 92161

[2] UNIV CALIF SAN DIEGO,NEUROL SERV,LA JOLLA,CA 92093

来源：

BRAIN RESEARCH | 1993年 / 601卷 / 1-2期

关键词：

NERVE GROWTH FACTOR; NUCLEUS BASALIS MAGNOCELLULARIS; CORTICAL CHOLINERGIC NEURON; CHOLINE ACETYLTRANSFERASE;

D O I：

10.1016/0006-8993(93)91731-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lesions of the nucleus basalis magnocellularis (NBM) increased the number of neurons in the frontal neocortex staining for choline acetyltransferase (ChAT). Intracerebroventricular treatment with nerve growth factor (NGF; 10 mug per day for 6 weeks) did not further increase this number. NGF increased the size of NBM neurons [Brain Res., 584 (1992) 55-63], but not those in the neocortex. However, NGF increased the area of ChAT-positive fiber staining in the neocortex. These data suggest that NGF enhances cholinergic innervation to the neocortex by affecting residual NBM neurons, rather than cortical cholinergic neurons.

引用

收藏

页码：329 / 332

页数：4

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