DOSE-DEPENDENT STUDY OF LIVER LIPID-PEROXIDATION RELATED PARAMETERS IN RATS TREATED WITH PP'-DDT

被引：16

作者：

BARROS, SBM ^{[1
]}

PIMENTE, R ^{[1
]}

SIMIZU, K ^{[1
]}

AZZALIS, LA ^{[1
]}

COSTA, IS ^{[1
]}

JUNQUEIRA, VBC ^{[1
]}

机构：

[1] UNIV SAO PAULO,INST QUIM,SAO PAULO,BRAZIL

来源：

TOXICOLOGY LETTERS | 1994年 / 70卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

DDT; LIPID PEROXIDATION; ACUTE INTOXICATION; LIVER;

D O I：

10.1016/0378-4274(94)90141-4

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Rats treated with increasing doses of pp'-DDT (60, 100 and 180 mg/kg body wt.) i.p., for 24 h, showed a dose-independent increase in liver cytochrome P450 levels, together with an increase in lipid peroxidation, measured as production of thiobarbituric acid reactants. This oxidant condition elicited in the liver by DDT was not accompanied by any change in the activity of NADPH-cytochrome c reductase or in the rate of superoxide anion generation by liver microsomal fraction. The activities of superoxide dismutase and glutathione peroxidase were found to be increased in the higher dose DDT-treated rats, without any change in those from catalase and glutathione reductase. The results presented showed an oxidant condition in the liver elicited by DDT treatment of rats, without any adequate hypothesis proposed to explain these data.

引用

页码：33 / 38

页数：6

共 23 条

[1] METABOLISM-DEPENDENT BINDING OF THE CHLORINATED INSECTICIDE DDT AND ITS METABOLITE, DDD, TO MICROSOMAL PROTEIN AND LIPIDS [J].