GENOMIC IMPRINTING - CONTROL OF GENE-EXPRESSION BY EPIGENETIC INHERITANCE

被引：45

作者：

SURANI, MA

机构：

[1] Wellcome/CRC Institute of Cancer and Developmental Biology, Cambridge, CB2 1QR, Tennis Court Road

[2] Physiological Laboratory, University of Cambridge, Cambridge

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 03期

关键词：

D O I：

10.1016/0955-0674(94)90031-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One parental copy of an imprinted gene is invariably expressed during development. The characteristic of the heritable epigenetic germline imprint remains elusive, but recent evidence stresses the necessity for additional post-zygotic epigenetic modifications to account for this temporal and tissue-specific mono-allelic expression. Preliminary insight into a diversity of post-zygotic control mechanisms is beginning to emerge.

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页码：390 / 395

页数：6

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