TERPENDOLES, NOVEL ACAT INHIBITORS PRODUCED BY ALBOPHOMA-YAMANASHIENSIS .2. STRUCTURE ELUCIDATION OF TERPENDOLE-A, TERPENDOLE-B, TERPENDOLE-C AND TERPENDOLE-D

被引：45

作者：

HUANG, XH

NISHIDA, H

TOMODA, H

TABATA, N

SHIOMI, K

YANG, DJ

TAKAYANAGI, H

OMURA, S

机构：

[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 01期

关键词：

D O I：

10.7164/antibiotics.48.5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.

引用

收藏

页码：5 / 11

页数：7

相关论文

共 19 条

[1]

BEURSKENS PT, 19841 CRYST LAB TECH

[2]

Cromer D.T, 1974, INT TABLES XRAY CRYS, VIV

[3] TREMORGENIC MYCO-TOXINS FROM PENICILLIUM-CRUSTOSUM - STRUCTURE ELUCIDATION AND ABSOLUTE-CONFIGURATION OF PENITREMS-B-F [J].

DE JESUS, AE ;

STEYN, PS ;

VAN HEERDEN, FR ;

VLEGGAAR, R ;

WESSELS, PL ;

HULL, WE .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1983, (08) :1857-1861

[4] STRUCTURE AND BIOSYNTHESIS OF THE PENITREMS-A-F, 6 NOVEL TREMORGENIC MYCO-TOXINS FROM PENICILLIUM-CRUSTOSUM [J].

DE JESUS, AE ;

STEYN, PS ;

VAN HEERDEN, FR ;

VLEGGAAR, R ;

WESSELS, PL ;

HULL, WE .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (06) :289-291

[5] TREMORGENIC MYCO-TOXINS FROM PENICILLIUM-CRUSTOSUM - ISOLATION OF PENITREMS A-F AND THE STRUCTURE ELUCIDATION AND ABSOLUTE-CONFIGURATION OF PENITREM-A [J].

DE JESUS, AE ;

STEYN, PS ;

VAN HEERDEN, FR ;

VLEGGAAR, R ;

WESSELS, PL ;

HULL, WE .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1983, (08) :1847-1856

[6] STRUCTURE ELUCIDATION OF THE JANTHITREMS, NOVEL TREMORGENIC MYCOTOXINS FROM PENICILLIUM-JANTHINELLUM [J].

DEJESUS, AE ;

STEYN, PS ;

VAN HEERDEN, FR ;

VLEGGAAR, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (04) :697-701

[7] TREMORGENIC NEUROTOXINS FROM PERENNIAL RYEGRASS CAUSING RYEGRASS STAGGERS DISORDER OF LIVESTOCK - STRUCTURE ELUCIDATION OF LOLITREM-B [J].

GALLAGHER, RT ;

HAWKES, AD ;

STEYN, PS ;

VLEGGAAR, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (09) :614-616

[8] AFLATREM, A TREMORGENIC TOXIN FROM ASPERGILLUS-FLAVUS [J].

GALLAGHER, RT ;

CLARDY, J ;

WILSON, BJ .

TETRAHEDRON LETTERS, 1980, 21 (03) :239-242

[9] JANTHITREMS - FLUORESCENT TREMORGENIC TOXINS PRODUCED BY PENICILLIUM-JANTHINELLUM ISOLATES FROM RYEGRASS PASTURES [J].

GALLAGHER, RT ;

LATCH, GCM ;

KEOGH, RG .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1980, 39 (01) :272-273

[10] MITHRIL - AN INTEGRATED DIRECT-METHODS COMPUTER-PROGRAM [J].

GILMORE, CJ .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1984, 17 (FEB) :42-46