STOMACH CARCINOGENICITY OF CAFFEIC ACID, SESAMOL AND CATECHOL IN RATS AND MICE

被引：63

作者：

HIROSE, M

FUKUSHIMA, S

SHIRAI, T

HASEGAWA, R

KATO, T

TANAKA, H

ASAKAWA, E

ITO, N

机构：

[1] First Department of Pathology, Nagoya City University Medical School, Nagoya, 467, Mizuho-ku

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 03期

关键词：

Antioxidants; Carcinogenicity; Mouse; Rat;

D O I：

10.1111/j.1349-7006.1990.tb02550.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The carcinogenic potential of caffeic acid, sesamol and catechol was examined in male and female F344 rats and B6C3F1 mice, groups of 30 animals being treated with diets containing 2% caffeic acid, 2% sesamol or 0.8% catechol for 104 weeks (rats) or 96 weeks (mice). Histological examination revealed that caffeic acid induced forestomach squamous cell carcinoma in 57% (P<0.001 vs. controls) and 50% (P<0.001) of male and female rats, respectively, whereas sesamol was associated with squamous cell carcinoma at incidences of 31% (P<0.001) in male rats, and 38% (P<0.001) and 17% (P<0.05) in male and female mice, respectively. Catechol induced glandular stomach adenocarcinomas in 54% (P<0.001) and 43% (P<0.001) of male and female rats, respectively. The results thus clearly demonstrated that all three antioxidants are carcinogenic in rodent stomach epithelia. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：207 / 212

页数：6

共 25 条

[1]

ATCHISON M, 1982, JNCI-J NATL CANCER I, V69, P503

[2]

BRANDT K, 1986, J AM COLL TOXICOL, V5, P123

[3] QUANTITATIVE-ANALYSIS OF CATECHOL AND 4-METHYLCATECHOL IN HUMAN-URINE [J].