THE APPLICATIONS OF NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY TO THE ANALYSIS OF POLYMORPHIC FORMS OF CIMETIDINE

被引：40

作者：

TUDOR, AM

DAVIES, MC

MELIA, CD

LEE, DC

MITCHELL, RC

HENDRA, PJ

CHURCH, SJ

机构：

[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,WELWYN AL6 9AR,WALES

[3] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND

[4] COURTAULDS RES,COVENTRY CV6 5RS,ENGLAND

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 1991年 / 47卷 / 9-10期

关键词：

D O I：

10.1016/0584-8539(91)80229-C

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Fourier transform (FT)-Raman spectroscopy, utilizing a near-infrared (Nd: YAG laser, at 1.064-mu-m) source was used to characterise the three anhydrous polymorphic forms A, B and C of the drug cimetidine (N"-cyano-N-methyl-N'-[2-[(5-methyl-1H-imidazol-4-yl) methylthio]ethyl]guanidine). The FT-Raman spectra were free from fluorescence interference and had good signal-to-noise ratios. Each polymorph has a distinct spectrum, characterised by two regions, 1250-1050 cm-1 and 1500-1350 cm-1. This work demonstrates that it is possible to use FT-Raman spectroscopy to differentiate between polymorphic forms of the same compound.

引用

页码：1389 / 1393

页数：5

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