SYSTEMIC ADMINISTRATION OF INTERLEUKIN-1 INDUCES PRETERM PARTURITION IN MICE

被引:282
作者
ROMERO, R
MAZOR, M
TARTAKOVSKY, B
机构
[1] SOROKA MED CTR,IL-84101 BEER SHEVA,ISRAEL
[2] WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL
关键词
INTERLEUKIN-1; CYTOKINES; PARTURITION; LABOR; CHORIOAMNIONITIS; PREMATURITY; PRETERM LABOR; MICE;
D O I
10.1016/0002-9378(91)90450-6
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Interleukin-1 has been postulated as a signal for the initiation of preterm labor and delivery. Interleukin-1 is produced by human decidua, stimulates prostaglandin production by intrauterine tissues, and is present in the amniotic fluid of women with preterm labor and intraamniotic infection. The purpose of these studies was to determine whether interleukin-1 could induce parturition in an animal species. Timed-pregnant C3H/HeJ inbred mice (n = 24) (genetically endotoxin resistant) were randomized to receive either recombinant human interleukin-1 or sterile phosphate-buffered saline solution between days 15 and 17 of gestation (normal length of pregnancy, 20 to 21 days). Three consecutive subcutaneous injections of interleukin-1 or phosphate-buffered saline solution were administered within 6 hours. Examinations of the animals were performed by blinded observers. Parturition occurred within 24 hours in all of the interleukin-1-treated mice and in none of the control group. Vaginal bleeding was first noted 4 hours after the first interleukin-1 injection, and delivery began within 12 hours after the last interleukin-1 injection. Premature delivery occurred in all interleukin-1-injected mice. Laparotomy revealed that there were no remaining fetuses in utero. All mice in the control group delivered spontaneously between days 20 and 22. We conclude that systemic administration of interleukin-1 induces preterm labor and delivery in mice.
引用
收藏
页码:969 / 971
页数:3
相关论文
共 20 条
  • [1] BEJAR R, 1981, OBSTET GYNECOL, V57, P479
  • [2] PRETERM LABOR - STIMULATION OF ARACHIDONIC-ACID METABOLISM IN HUMAN AMNION CELLS BY BACTERIAL PRODUCTS
    BENNETT, PR
    ROSE, MP
    MYATT, L
    ELDER, MG
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1987, 156 (03) : 649 - 655
  • [3] SECRETION OF PHOSPHOLIPASES BY BACTERIAL PATHOGENS MAY INITIATE PRETERM LABOR
    BENNETT, PR
    ELDER, MG
    MYATT, L
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (01) : 241 - 242
  • [4] PRODUCTION OF PROSTAGLANDIN-E2 BY HUMAN AMNION INVITRO IN RESPONSE TO ADDITION OF MEDIA CONDITIONED BY MICROORGANISMS ASSOCIATED WITH CHORIOAMNIONITIS AND PRETERM LABOR
    LAMONT, RF
    ANTHONY, F
    MYATT, L
    BOOTH, L
    FURR, PM
    TAYLORROBINSON, D
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 162 (03) : 819 - 825
  • [5] LAMONT RF, 1985, LANCET, V2, P1131
  • [6] PHOSPHOLIPASE-C ACTIVITY IN MICROORGANISMS ASSOCIATED WITH REPRODUCTIVE-TRACT INFECTION
    MCGREGOR, JA
    LAWELLIN, D
    FRANCOBUFF, A
    TODD, JK
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 164 (02) : 682 - 686
  • [7] PROSTAGLANDIN BIOSYNTHESIS BY HUMAN DECIDUAL CELLS - EFFECTS OF INFLAMMATORY MEDIATORS
    MITCHELL, MD
    EDWIN, S
    ROMERO, RJ
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1990, 41 (01): : 35 - 38
  • [8] MITCHELL MD, IN PRESS PROSTAGLAND
  • [9] NETA R, 1988, LYMPHOKINE RES, V7, P403
  • [10] POSSIBLE MEDIATORS IN ENDOTOXIN-INDUCED ABORTION
    PARANT, M
    [J]. RESEARCH IN IMMUNOLOGY, 1990, 141 (02): : 164 - 168