PROLACTIN GENE-EXPRESSION IN HUMAN THYMOCYTES

被引：60

作者：

ONEAL, KD

MONTGOMERY, DW

TRUONG, TM

YULEE, LY

机构：

[1] BAYLOR COLL MED,DEPT MED,ROOM 544E,1 BAYLOR PLAZA,HOUSTON,TX 77030

[2] BAYLOR COLL MED,DEPT CELL BIOL,HOUSTON,TX 77030

[3] BAYLOR COLL MED,DEPT MICROBIOL & IMMUNOL,HOUSTON,TX 77030

[4] UNIV ARIZONA,COLL MED,DEPT PHARMACOL,TUCSON,AZ 85723

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1992年 / 87卷 / 1-3期

关键词：

PROLACTIN; CYTOKINE; THYMOCYTE; CDNA SEQUENCE;

D O I：

10.1016/0303-7207(92)90251-Z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent evidence suggests that lymphocytes produce prolactin (PRL). Here, we report the cDNA cloning and expression of PRL from normal human thymocytes. Sequence analysis showed that the thymocyte cDNA encodes a 23 kDa protein which is identical to pituitary PRL. RNA blot analysis showed that the thymocyte PRL mRNA is approximately 170 nucleotides larger than the pituitary PRL message. PRL message was also detected in several non-pituitary human cell lines including Jurkat T, HeLa, and JEG cells. Furthermore, PRL gene expression in JEG cells was inhibited by glucocorticoid treatment. Our data support the hypothesis that PRL is a T cell-derived cytokine.

引用

页码：R19 / R23

页数：5

共 17 条

[1] VASOACTIVE INTESTINAL PEPTIDE INCREASES PROLACTIN MESSENGER RIBONUCLEIC-ACID CONTENT IN GH3-CELLS [J].