INFLUENCE OF CIRCADIAN-STAGE-DEPENDENT DOSING SCHEDULE ON NEPHROTOXICITY AND PHARMACOKINETICS OF ISEPAMICIN IN RATS

被引：25

作者：

YOSHIYAMA, Y

NISHIKAWA, S

SUGIYAMA, T

KOBAYASHI, T

SHIMADA, H

TOMONAGA, F

OHDO, S

OGAWA, N

NAKANO, S

机构：

[1] EHIME UNIV,SCH MED,DEPT PHARMACOL,SHIGENOBU,EHIME 79102,JAPAN

[2] OITA MED UNIV,DEPT CLIN PHARMACOL & THERAPEUT,OITA 87955,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 09期

关键词：

D O I：

10.1128/AAC.37.9.2042

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

引用

页码：2042 / 2043

页数：2

共 7 条

[1] CIRCADIAN VARIATION IN SERUM AMIKACIN LEVELS [J].