DEVELOPMENTAL DEFECTS IN BRAIN SEGMENTATION CAUSED BY MUTATIONS OF THE HOMEOBOX GENES ORTHODENTICLE AND EMPTY SPIRACLES IN DROSOPHILA

被引：167

作者：

HIRTH, F ^{[1
]}

THERIANOS, S ^{[1
]}

LOOP, T ^{[1
]}

GEHRING, WJ ^{[1
]}

REICHERT, H ^{[1
]}

FURUKUBOTOKUNAGA, K ^{[1
]}

机构：

[1] UNIV BASEL,BIOCTR,DEPT CELL BIOL,CH-4056 BASEL,SWITZERLAND

来源：

NEURON | 1995年 / 15卷 / 04期

关键词：

D O I：

10.1016/0896-6273(95)90169-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied the roles of the homeobox genes orthodenticle (otd) and empty spiracles (ems) in embryonic brain development of Drosophila. The embryonic brain is composed of three segmental neuromeres. The otd gene is expressed predominantly in the anterior neuromere; expression of ems is restricted to the two posterior neuromeres. Mutation of otd eliminates the first (protocerebral) brain neuromere. Mutation of ems eliminates the second (deutocerebral) and third (tritocerebral) neuromeres. otd is also necessary for development of the dorsal protocerebrum of the adult brain. We conclude that these homeobox genes are required for the development of specific brain segments in Drosophila, and that the regionalized expression of their homologs in vertebrate brains suggests an evolutionarily conserved program for brain development.

引用

页码：769 / 778

页数：10

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