IDENTIFICATION OF METABOLITES OF TIROPRAMIDE IN HUMAN-URINE

被引:14
作者
ARIGONI, R
CHISTE, R
MAKOVEC, F
SETNIKAR, I
BENFENATI, E
FANELLI, R
机构
[1] ROTTA RES LAB SPA, VIA VALOSA SOPRA 7, I-20052 MONZA, ITALY
[2] IST MARIO NEGRI, MILANO, ITALY
来源
BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY | 1988年 / 15卷 / 04期
关键词
D O I
10.1002/bms.1200150404
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
The metabolites of tiropramide were extracted from the urine of healthy volunteers given tiropramide hydrochloride orally. Eight metabolites of tiropramide were found by gas chromatography/mass spectrometry. Three were identified on the basis of their mass spectra, retention times and comparison with synthetic standards. For the others a probable structure is proposed on the basis of their mass spectra.
引用
收藏
页码:205 / 209
页数:5
相关论文
共 3 条
[1]  
ARIGONI R, 1986, ARZNEIMITTELFORSCH, V36-1, P738
[2]  
MAKOVEC F, 1975, CHEM ABSTR, V83, P505
[3]  
SEGRE G, 1984, FARMACI S3, V8, P1