THROMBOMODULIN, AN ENDOTHELIAL ANTICOAGULANT - ITS STRUCTURE, FUNCTION AND EXPRESSION

被引：27

作者：

MARUYAMA, I

机构：

来源：

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION | 1992年 / 56卷 / 02期

关键词：

ENDOTHELIAL CELLS; THROMBOMODULIN; PROTEIN-C; CYTOKINE; THROMBOSIS;

D O I：

10.1253/jcj.56.187

中图分类号：

N09 [自然科学史]; B [哲学、宗教];

学科分类号：

01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;

摘要：

Thrombomodulin is an endothelium-associated glycoprotein that converts thrombin from a procoagulant protease to an anticoagulant. Thrombin, a key enzyme in thrombus formation, binds to thrombomodulin on the endothelium. However after thrombin binds to thrombomodulin, it fails to act on the coagulation factors and platelets, and its ability to activate protein C is enhanced more than 1,000-fold. This article reviews the recent progress in the study of thrombomodulin.

引用

页码：187 / 191

页数：5

共 19 条

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[2]

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