MICROENCAPSULATION WITHIN CROSS-LINKED POLYETHYLENEIMINE MEMBRANES

被引：24

作者：

PONCELET, D

ALEXAKIS, T

DESMET, BP

NEUFELD, RJ

机构：

[1] Department of Chemical Engineering, McGill University, Montreal, QC, H3A 2A7

来源：

JOURNAL OF MICROENCAPSULATION | 1994年 / 11卷 / 01期

关键词：

D O I：

10.3109/02652049409040436

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A microencapsulation technique is proposed involving the formation of a polyethyleneimine (PEI) membrane crosslinked by an acid dichloride. The membranes were formed at pH 8 in a non-polar solvent, conditions which are better suited for the encapsulation of biocatalysts or fragile biochemicals than those using polyamide membranes. The mean diameter and size distribution of the PEI microcapsules were similar to that observed with nylon membranes. The resultant microcapsules were spherical, free-flowing with a strong membrane. The mass of membrane was seen to be independent of the reaction time (1-4 min), insensitive to the PEI concentration and proportional to the concentration of crosslinking agent.

引用

页码：31 / 40

页数：10

共 27 条

[1]

Alexakis T., Microencapsulation of DNA within cross-linked chitosan membranes, (1992)

[2]

Birnbaum S., Pendleton R., Larsson P.O., Mosbach K., Covalent stabilization of alginate gel for the entrapment of living whole cells, Biotechnology Letters, 3, pp. 393-400, (1981)

[3]

Brink L.E.S., Tramper J., Optimization of organic solvent in multiphase biocatalysis, Biotechnology and Bioengineering, 27, pp. 1258-1269, (1985)

[4]

Champagne C.P., Boyaval P., Les cellules immobilisees et l'industrie laitière, Technique laitiére, 1015, pp. 26-32, (1986)

[5]

Chang T.M.S., Semipermeable microcapsules, Science, 1, pp. 524-525, (1964)

[6]

Chang T.M.S., Artificial cells in medicine and biotechnology, Applied Biochemistry and Biotechnology, 10, pp. 5-21, (1984)

[7]

Dueck C.L., Neufeld R.J., Chang T.M.S., Hydrodynamics and urea hydrolysis in a microencapsulated urease, fluidized bed reactor, Canadian Journal of Chemical Engineering, 64, pp. 540-546, (1986)

[8]

Grunwald J., Chang T.M.S., Nylon polyethyleneimine microcapsules for immobilizing multienzymes with soluble dextran-NAD+ for the continuous recycling of the microencapsulated dextran-NAD+, Biochemical and Biophysical Research Communications, 81, pp. 565-570, (1978)

[9]

Horn D., Polyethylene–physicochemical properties and applications. Polymeric Amines and Ammonium Salts, pp. 333-356, (1980)

[10]

Hyndeman C.L., Groboillot A.F., Poncelet D., Champagne C.P., Neufeld R.J., Microencapsulation of Lactococcus lactis within cross-linked gelatin membranes, Journal of Chemical Technology and Biotechnology, (1992)

← 1 2 3 →