THE INVOLVEMENT OF N-METHYL-D-ASPARTATE (NMDA) AND NON-NMDA RECEPTORS IN THE RESPONSIVENESS OF RAT SPINAL NEURONS WITH INPUT FROM THE CHRONICALLY INFLAMED ANKLE

被引：40

作者：

NEUGEBAUER, V ^{[1
]}

LUCKE, T ^{[1
]}

GRUBB, B ^{[1
]}

SCHAIBLE, HG ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHYSIOL,D-97070 WURZBURG,GERMANY

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 02期

关键词：

NMDA RECEPTOR ANTAGONIST; NON-NMDA RECEPTOR ANTAGONIST; RAT SPINAL CORD; JOINT NOCICEPTION; ARTHRITIS; KETAMINE; AP5; CNQX;

D O I：

10.1016/0304-3940(94)90327-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Unilateral adjuvant inflammation was induced at the rat ankle 2 or 20 days before an evaluation of the contribution of N-methyl-D-aspartate (NMDA) and non-NMDA receptors to the processing of nociceptive information by wide dynamic range neurons in the spinal cord. Microionophoretic application of either the NMDA receptor antagonists ketamine and DL-2-amino-5-phosphonovalerate (AP5) or the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the responses to innocuous and noxious mechanical stimulation of the inflamed ankle. The pattern of these effects was comparable to that in rats with acute inflammation suggesting that non-NMDA and NMDA receptors are similarly involved in acute, prolonged acute and chronic inflammation-evoked activity.

引用

页码：237 / 240

页数：4

共 29 条

[1] DORSAL HORN (CONVERGENT) NEURONS IN THE INTACT ANESTHETIZED ARTHRITIC RAT .1. SEGMENTAL EXCITATORY INFLUENCES [J].