A MONOCLONAL-ANTIBODY TO ALPHA-4 INTEGRIN SUPPRESSES AND REVERSES ACTIVE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

被引：184

作者：

KENT, SJ

KARLIK, SJ

CANNON, C

HINES, DK

YEDNOCK, TA

FRITZ, LC

HORNER, HC

机构：

[1] UNIV WESTERN ONTARIO HOSP,DEPT DIAGNOST RADIOL,LONDON,ON N6A 5A5,CANADA

[2] UNIV WESTERN ONTARIO HOSP,DEPT NUCL MED,LONDON,ON N6A 5A5,CANADA

[3] UNIV WESTERN ONTARIO HOSP,DEPT PHYSIOL,LONDON,ON N6A 5A5,CANADA

[4] ATHENA NEUROSCI,S SAN FRANCISCO,CA 94080

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 58卷 / 01期

关键词：

ADHESION MOLECULES; VLA4; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; TREATMENT; ALPHA-4-BETA-1; INTEGRIN;

D O I：

10.1016/0165-5728(94)00165-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In experimental allergic encephalomyelitis (EAE), circulating leukocytes enter the central nervous system (CNS) producing inflammation, myelin damage and paralysis. Prevention of leukocyte infiltration by an antibody against alpha 4 integrin suppressed clinical and pathological features of EAE in the guinea pig. Rapid clearance of leukocytes from the CNS and reversal of clinical findings were observed when anti-alpha 4 treatment was administered during active disease. Clinical improvement was accompanied by a marked decrease in abnormal pathological findings, including demyelination. Therefore anti-alpha 4 is an effective treatment of EAE and may be similarly useful in the treatment of autoimmune diseases such as multiple sclerosis.

引用

页码：1 / 10

页数：10

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