PRIMARY ALDOSTERONISM IN PREGNANCY - SHOULD IT BE TREATED SURGICALLY

被引:16
作者
ABOUD, E [1 ]
DESWIET, M [1 ]
GORDON, H [1 ]
机构
[1] NORTHWICK PK HOSP & CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND
关键词
D O I
10.1007/BF02967204
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a case of primary aldosteronism in pregnancy that was treated surgically by removal of the adenoma in the 2nd trimester. Only a few cases have been reported in the English literature due to the rarity of the condition, Primary aldosteronism follows a variable course in pregnancy, In the majority of cases the hypertension and hypokalaemia are made worse, necessitating antihypertensive medication to control the blood pressure, Some of the drugs required for treatment are known to affect the fetus, In a minority of cases the hypertension improves with pregnancy, This is thought to to be due to the high levels of progesterone which is an aldosterone antagonist, Primary aldosteronism invariably gets worse in the post partum period, irrespective of the ante natal course of the disease, Surgery seems to be the treatment of choice for this condition, provided the adenoma is localised, It has the advantage of offering an immediate solution, avoids fetal complications of medical treatment and possible deterioration in the post partum period.
引用
收藏
页码:279 / 280
页数:2
相关论文
共 12 条
[1]  
Crane M.G., Andes J.P., Harris J.J., Slate W.G., Primary aldosteronism in pregnancy, Obstet. Gynecol., 23, pp. 200-208, (1964)
[2]  
Neerhof M.G., Shlossman P.A., Poll D.S., Ludomirsky A., Weiner S., Idiopathic aldosteronism in pregnancy, Obstet. Gynecol., 3, 78, pp. 489-491, (1991)
[3]  
Levy J., Marx G.F., Problems related to aldosteronism during Caesarean section, Anesthesiology, 34, pp. 294-297, (1971)
[4]  
Hammond T.G., Buchanan J.D., Scoggins B.A., Thatcher R., Withworth J.A., Primary hyperaldosteronism in pregnancy, Aust. N.Z. J. Med., 12, pp. 537-539, (1982)
[5]  
Elterman J.J., Hagen G.A., Aldosteronism in pregnancy: association with virilization of female offspring, South Med. J., 76, pp. 514-516, (1983)
[6]  
Merrill R.H., Dombroski R.A., MacKenna J.M., Primary hyperaldosteronism during pregnancy, Am. J. Obstet. Gynecol., 150, pp. 786-787, (1984)
[7]  
Lotgering F.K., Derky F.M., Wallenburg H.C., Primary hyperaldosteronism in pregnancy, Am. J. Obstet. Gynecol., 155, pp. 986-988, (1986)
[8]  
Gordon R.D., Fishman L.M., Liddle G.W., Plasma renin activity and aldosterone secretion in a pregnant woman with primary hyperaldosteronism, J. Clin. Endocrinol. Metab., 27, pp. 385-388, (1967)
[9]  
Colton R., Perez G.O., Fishman L.M., Primary aldosteronism in pregnancy, Am. J. Obstet. Gynecol., 150, pp. 892-893, (1984)
[10]  
Biglieri E.G., Slaton P.E., Pregnancy and primary aldosteronism, J. Clin. Endocrinol. Metab., 27, pp. 1628-1632, (1967)