THE DROSOPHILA KINESIN-LIKE PROTEIN KLP3A IS A MIDBODY COMPONENT REQUIRED FOR CENTRAL SPINDLE ASSEMBLY AND INITIATION OF CYTOKINESIS

被引：146

作者：

WILLIAMS, BC ^{[1
]}

RIEDY, MF ^{[1
]}

WILLIAMS, EV ^{[1
]}

GATTI, M ^{[1
]}

GOLDBERG, ML ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,IST PASTEUR FDN CENCI BOLOGNETTI,DIPARTIMENTO GENET & BIOL MOLEC,I-00185 ROME,ITALY

来源：

JOURNAL OF CELL BIOLOGY | 1995年 / 129卷 / 03期

关键词：

D O I：

10.1083/jcb.129.3.709

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We describe here a new member of the kinesin superfamily in Drosophila, KLP3A (Kinesin Like-Protein-at-3A). The KLP3A protein localizes to the equator of the central spindle during late anaphase and telophase of male meiosis. Mutations in the KLP3A gene disrupt the interdigitation of microtubules in spermatocyte central spindles. Despite this defect, anaphase B spindle elongation is not obviously aberrant. However, cytokinesis frequently fails after both meiotic divisions in mutant testes. Together, these findings strongly suggest that the KLP3A presumptive motor protein is a critical component in the establishment or stabilization of the central spindle. Furthermore, these results imply that the central spindle is the source of signals that initiate the cleavage furrow in higher cells.

引用

页码：709 / 723

页数：15

共 64 条

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