EXPRESSION OF HLA ABC AND DR ANTIGENS IN THYROID NEOPLASIA AND CORRELATION WITH MONONUCLEAR LEUKOCYTE INFILTRATION

被引:12
作者
FISFALEN, ME [1 ]
FRANKLIN, WA [1 ]
DEGROOT, LJ [1 ]
CAJULIS, RS [1 ]
SOLTANI, K [1 ]
RYAN, M [1 ]
JONES, N [1 ]
机构
[1] UNIV CHICAGO,DEPT MED,THYROID STUDY UNIT,5841 S MARYLAND AVE,CHICAGO,IL 60637
关键词
Antigen; autoimmune; epithelium; expression; infiltration; lymphocyte; monoclonal antibodies;
D O I
10.1007/BF03348579
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The rejection of tumor cells by the immune system depends on the production of tumor-associated antigens and the expression of HLA antigens on these cells. We therefore studied the expression of HLA ABC and PR antigens in malignant and benign thyroid disorders and correlated it with the types and extent of mononuclear cell infiltration. In the normal thyroid, HLA ABC expression was weak and focal, while it was diffusely present in benign disorders and in most but not all malignancies. HLA DR antigens, while absent or infrequently expressed in normal thyroid, were strongly but often focally expressed in all cases of autoimmune thyroid disease (AITD), as well as in most cases of malignant tumors and benign epithelium surrounding these tumors, and colloid nodule diesase. There was a T cell predominance in all disorders, and the CD4VCD8+ ratio was > 1 in most benign and malignant specimens. There was a direct correlation between the high expression of HLA antigens and dense inflammatory infiltration in AITD but not in most tumor specimens. Lack of such correlation suggests that the expression of HLA antigens is an autonomous event in tumors, independent of cellular infiltrate. © 1990, Italian Society of Endocrinology (SIE). All rights reserved.
引用
收藏
页码:41 / 48
页数:8
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