NONENZYMATIC GLYCATION ALTERS PROPERTIES OF COLLAGEN AS A SUBSTRATUM FOR CELLS

被引：17

作者：

KAWANO, E ^{[1
]}

TAKAHASHI, S ^{[1
]}

SAKANO, Y ^{[1
]}

FUJIMOTO, D ^{[1
]}

机构：

[1] TOKYO UNIV AGR & TECHNOL,FAC AGR,DEPT AGR CHEM,FUCHU,TOKYO 183,JAPAN

来源：

MATRIX | 1990年 / 10卷 / 05期

关键词：

cell substratum; collagen; nonenzymatic glycation;

D O I：

10.1016/S0934-8832(11)80185-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Acid-soluble collagen from rat skin was glycated in vitro by incubating with 0.2 M D-ribose at 37 °C for several days, and properties of the glycated collagen as a substratum for fibroblasts 3Y1 were studied. The cells attached but spread poorly on the glycated collagen as compared with on the untreated collagen. Thymidine incorporation by the cells on the glycated collagen was higher than that by the cells on untreated collagen. These results indicate that the glycation significantly alters properties of collagen as a substratum for cells. © 1990, Gustav Fischer Verlag · Stuttgart · New York. All rights reserved.

引用

页码：300 / 305

页数：6

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