EFFECT OF A LEUKOTRIENE ANTAGONIST, ONO-1078, ON BRONCHIAL HYPERRESPONSIVENESS IN PATIENTS WITH ASTHMA

被引:89
作者
FUJIMURA, M [1 ]
SAKAMOTO, S [1 ]
KAMIO, Y [1 ]
MATSUDA, T [1 ]
机构
[1] KANAZAWA UNIV HOSP,CENT CLIN LAB,KANAZAWA 920,JAPAN
关键词
D O I
10.1016/0954-6111(93)90141-L
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To evaluate the involvement of sulphidopeptide leukotrienes on bronchial hyperresponsiveness in astham, we examined the effects of a specific orally active leukotriene antagonist (ONO-1078) on bronchial responsiveness to methacholine in stable asthmatic subjects by a double-blinded, randomized, two-phase crossover study. Eleven asthmatic subjects received ONO-1078 (225 mg twice a day) or placebo. After 1 week administration of ONO-1078 or placebo, the subjects underwent methacholine challenge test. Test drug administrations were then discontinued for 1 week, and the subjects were then crossed over to the alternative treatment regimen. After 1 week of the alternate regimen, the subjects underwent a second methacholine challenge. Mean baseline values of forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) and geometric mean value of provocative concentration of methacholine causing a 20% fall in FEV1 (PC20-FEV1) were equal between the first and the second methacholine test. The geometric mean value of PC20-FEV1 after the administration of ONO-1078 was 0·48 (geometric sem, 1·48) mg ml-1, which was significantly (P<0·01) greater than the value after the placebo administration (0·30 geometric sem, 1·41 mg ml-1), but the baseline values of FVC and FEV1 were not altered by ONO-1078. We conclude that sulphidopeptide leukotrienes are significantly involved in the development of bronchial hyperresponsiveness in asthma but the degree of the involvement may be small. © 1993.
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页码:133 / 138
页数:6
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