ESR SPECTROSCOPY OF FLOW-ORIENTED CATION RADICALS OF PHENOTHIAZINE-DERIVATIVES AND PHENOXATHIIN INTERCALATED IN DNA

被引：18

作者：

STOLZE, K ^{[1
]}

MASON, RP ^{[1
]}

机构：

[1] NIEHS,MOLEC BIOPHYS LAB,POB 12233,RES TRIANGLE PK,NC 27709

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1991年 / 77卷 / 03期

关键词：

ELECTRON SPIN RESONANCE; DNA; PHENOTHIAZINE; PHENOXATHIIN; FREE RADICALS; INTERCALATION;

D O I：

10.1016/0009-2797(91)90037-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several derivatives of the phenothiazine cation radicals intercalated into DNA have been investigated using a new flow orientation technique. The anistropic hyperfine coupling constants of both the parallel and the perpendicular orientation relative to the magnetic field were measured and compared to previous results, which used different techniques. The phenoxathiin cation radical could also be stabilized by intercalation into DNA at pH 4, but the orientation technique revealed no further information due to the poor resolution of the experimental spectra.

引用

页码：283 / 289

页数：7

共 8 条

[1] REACTIONS OF CHLORPROMAZINE CATION RADICAL WITH PHYSIOLOGICALLY OCCURRING NUCLEOPHILES [J].

CHENG, HY ;

SACKETT, PH ;

MCCREERY, RL .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (09) :948-952

[2] KINETICS OF CHLORPROMAZINE CATION RADICAL DECOMPOSITION IN AQUEOUS BUFFERS [J].

CHENG, HY ;

SACKETT, PH ;

MCCREERY, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (03) :962-967

[3] IRREVERSIBLE BINDING OF THE CHLORPROMAZINE RADICAL CATION AND OF PHOTOACTIVATED CHLORPROMAZINE TO BIOLOGICAL MACROMOLECULES [J].

DEMOL, NJ ;

BUSKER, RW .

CHEMICO-BIOLOGICAL INTERACTIONS, 1984, 52 (01) :79-92

[4] IRREVERSIBLE BINDING WITH BIOLOGICAL MACROMOLECULES AND EFFECTS IN BACTERIAL MUTAGENICITY TESTS OF THE RADICAL CATION OF PROMETHAZINE AND PHOTOACTIVATED PROMETHAZINE - COMPARISON WITH CHLORPROMAZINE [J].

DEMOL, NJ ;

BECHT, ABC ;

KOENEN, J ;

LODDER, G .

CHEMICO-BIOLOGICAL INTERACTIONS, 1986, 57 (01) :73-83

[5] ELECTRON-SPIN-RESONANCE OF CATION RADICALS OF PHENOTHIAZINE-DERIVATIVES [J].

MOTTEN, AG ;

CHIGNELL, CF .

MAGNETIC RESONANCE IN CHEMISTRY, 1985, 23 (10) :834-841

[6] INTERACTION OF RADICAL ION OF CHLORPROMAZINE WITH DEOXYRIBONUCLEIC ACID [J].

OHNISHI, SI ;

MCCONNELL, HM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (10) :2293-+

[7] ELECTRON-SPIN-RESONANCE STUDIES OF A CHLORPROMAZINE DERIVATIVE BOUND TO DNA FIBERS [J].

PORUMB, T ;

SLADE, EF .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1976, 65 (01) :21-24

[8] A NEW FLAT CELL FOR FLOW-ORIENTATION ELECTRON-SPIN-RESONANCE EXPERIMENTS [J].

STOLZE, K ;

MASON, RP .

JOURNAL OF MAGNETIC RESONANCE, 1987, 73 (02) :287-292

← 1 →