CGRP 8-37 BLOCKS THE INHIBITION OF GASTRIC-EMPTYING INDUCED BY INTRAVENOUS-INJECTION OF ALPHA-CGRP IN RATS

被引：14

作者：

PLOURDE, V

STPIERRE, S

FOURNIER, A

TACHE, Y

机构：

[1] UNIV CALIF LOS ANGELES, DEPT MED, LOS ANGELES, CA 90073 USA

[2] UNIV CALIF LOS ANGELES, VA MED CTR, CTR ULCER RES & EDUC, LOS ANGELES, CA 90073 USA

[3] UNIV CALIF LOS ANGELES, BRAIN RES INST, LOS ANGELES, CA 90073 USA

[4] UNIV QUEBEC, INRS SANTE, POINTE CLAIRE H9R 1G6, PQ, CANADA

来源：

LIFE SCIENCES | 1993年 / 52卷 / 10期

关键词：

D O I：

10.1016/0024-3205(93)90514-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The receptor subtype mediating rat alpha-calcitonin gene-related peptide (alpha-CGRP)-induced inhibition of gastric emptying of a non nutrient solution was tested in conscious rats using the CGRP1 receptor antagonist, CGRP 8-37, and the CCK antagonist, MK-329. Intravenous injection of alpha-CGRP (0.5 mug) decreased gastric emptying to 26.5 +/- 5.8% from 46.4 +/- 3.9% in vehicle-treated group. Intravenous injection of CGRP 8-37 (15 mug) did not influence gastric emptying but completely prevented alpha-CGRP inhibitory effect whereas the 47% delay in gastric emptying induced by intravenous cholecystokinin-8 (CCK, 0.25 mug) was not modified. The CCK antagonist, MK-329 (1 mg) reversed CCK- but not alpha-CGRP-induced delay in gastric emptying. These results demonstrate that CGRP 8-37 is a specific tool to block alpha-CGRP inhibitory action on gastric motor function and suggest that gastric stasis elicited by peripheral injection of alpha-CGRP may involve an interaction with a CGRP1 receptor subtype.

引用

页码：857 / 862

页数：6

共 23 条

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