GASTRIC ENDOCRINE CELL EVOLUTION IN PATIENTS WITH ZOLLINGER-ELLISON SYNDROME - INFLUENCE OF GASTRINOMA GROWTH AND LONG-TERM OMEPRAZOLE TREATMENT

被引:35
作者
CADIOT, G
LEHY, T
RUSZNIEWSKI, P
BONFILS, S
MIGNON, M
机构
[1] HOP BICHAT, INSERM, U10, 170 BLD NEY, F-75877 PARIS 18, FRANCE
[2] HOP BICHAT, DEPT GASTROENTEROL, F-75877 PARIS 18, FRANCE
关键词
ZOLLINGER-ELLISON SYNDROME; OMEPRAZOLE; GASTRIC ENDOCRINE CELLS; CELL QUANTIFICATION; SERUM GASTRIN CONCENTRATION; MULTIPLE ENDOCRINE NEOPLASIA TYPE-I;
D O I
10.1007/BF01296083
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Evolution of gastrinoma tumoral mass, fasting serum gastrin concentrations, and gastric endocrine cells has been analyzed in 21 patients with the Zollinger-Ellison syndrome committed to long-term omeprazole treatment (up to 7.75 years, median 37 months). Gastrinoma growth was seen in eight patients. Significant increase in serum gastrin was only observed in the group of patients with gastrinoma growth. Fundic argyrophil cell densities were correlated with serum gastrin (r' = 0. 68, P = 0. 002). Argyrophil and antral gastrin cell densities significantly increased during the survey, but increases were greater in the group with gastrinoma growth (respectively, + 136% and + 131%) than in the other group (respectively, +34% and +43%). Progression in the degree of argyrophil cell hyperplasia, noted qualitatively, was observed in 11 patients. Fundic carcinoids developed in three of these 11 patients, all three having multiple endocrine neoplasia type 1 (MEN 1). Positive linear individual correlations (r greater-than-or-equal-to 0.85) between argyrophil cell densities and corresponding durations of omeprazole treatment were found in nine of the 10 patients studied at least three times and who had a clear-cut increase in those cell densities. Thus, increase in serum gastrin and fundic argyrophil cell densities appeared closely associated with gastrinoma growth; however, duration of drug-induced hypochlorhydria may also affect cell proliferation.
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页码:1307 / 1317
页数:11
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