THE ANCIENT REGULATORY-PROTEIN FAMILY OF WD-REPEAT PROTEINS

被引：1336

作者：

NEER, EJ

SCHMIDT, CJ

NAMBUDRIPAD, R

SMITH, TF

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA

[2] BOSTON UNIV,DEPT PHARMACOL,BOSTON,MA 02215

[3] BOSTON UNIV,BIOMOLEC ENGN RES CTR,BOSTON,MA 02215

来源：

NATURE | 1994年 / 371卷 / 6495期

关键词：

D O I：

10.1038/371297a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.

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页码：297 / 300

页数：4

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