TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA IN CEREBROSPINAL-FLUID OF PATIENTS WITH COCCIDIOIDAL MENINGITIS DURING THERAPY WITH FLUCONAZOLE

被引：8

作者：

AMPEL, NM

AHMANN, DR

DELGADO, KL

GALGIANI, JN

CLOUD, GA

机构：

[1] VET ADM MED CTR,RES SERV,TUCSON,AZ 85723

[2] UNIV ARIZONA,COLL MED,DEPT MED,TUCSON,AZ

[3] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 06期

关键词：

D O I：

10.1093/infdis/171.6.1675

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1 beta in the cerebrospinal fluid (CSF) of 66 patients with coccidioidal meningitis during therapy with fluconazole were measured by ELISA, The median concentration of TNF-alpha was 15.2 pg/mL for 322 samples; for IL-1 beta, it was 4.7 pg/mL for 316 samples. There were no significant changes in the level of either cytokine over 24 months of follow-up nor was there an association between the initial CSF concentrations of TNF-alpha and IL-1 beta and subsequent fluconazole treatment failure, Over time, concentrations of IL-1 beta were significantly associated with both clinical symptoms and white blood cell counts in CSF, These results indicate that CSF levels of TNF-alpha and IL-1 beta are relatively low compared with those associated with acute bacterial meningitis.

引用

页码：1675 / 1678

页数：4

共 15 条

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