COMPARATIVE STUDIES ON ISOLATED RAT HEPATOCYTES AND AS-30D HEPATOMA-CELLS WITH LEUCOCIDIN FROM PSEUDOMONAS-AERUGINOSA

被引：28

作者：

FRIMMER, M

HOMANN, J

PETZINGER, E

RUFEGER, U

SCHARMANN, W

机构：

[1] UNIV GIESSEN, INST PHARMAKOL & TOKIKOL, D-6300 GIESSEN, FED REP GER

[2] UNIV GIESSEN, INST BAKTERIOL & IMMUNOL, D-6300 GIESSEN, FED REP GER

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1976年 / 295卷 / 01期

关键词：

D O I：

10.1007/BF00509774

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Leucocidin, 1 of the cytotoxic principles of P. aeruginosa, induces K loss and swelling in isolated hepatocytes and AS-30D ascites hepatoma cells in a dose and time dependent manner. Hepatoma cells are more sensitive than normal hepatocytes. As shown by scanning electron microscopy the volume increase of both types of cells is accompanied by disappearance of microvilli. In contrast to phalloidin poisoning, no protrusions were formed when the cells were exposed to leucocidin under isotonic conditions.

引用

页码：63 / 69

页数：7

共 12 条

[1]

BAUR H, 1971, THESIS TUBINGEN

[2] HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS - A BIOCHEMICAL AND FINE STRUCTURAL STUDY [J].