EFFICACY OF THE TRIAZOLE D0870 IN A MURINE MODEL OF SYSTEMIC HISTOPLASMOSIS

被引：15

作者：

CLEMONS, KV

STEVENS, DA

机构：

[1] CALIF INST MED RES,SAN JOSE,CA 95128

[2] STANFORD UNIV,DEPT MED,DIV INFECT DIS & GEOG MED,STANFORD,CA 94305

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 03期

关键词：

D O I：

10.1128/AAC.39.3.778

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The efficacy of D0870 was studied in a murine model of systemic histoplasmosis and was compared with that of fluconazole. All regimens of D0870 (1 or 10 mg/kg of body weight given daily or 1, 10, or 100 mg/kg given every other day) and 100 mg of fluconazole per kg given daily provided complete protection from lethality. Comparison of the number of viable Histoplasma capsulatum yeasts remaining in the spleen or liver indicated that D0870 was superior to fluconazole in clearing and curing infection. D0870 was 10- to 100-fold more efficacious than fluconazole in the treatment of experimental histoplasmosis.

引用

页码：778 / 780

页数：3

共 14 条

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